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Xingfan ZHOU,Zengling YANG,Longjian CHEN,Lujia HAN
《农业科学与工程前沿（英文）》 2016年 第3卷 第2期 页码 171-179 doi: 10.15302/J-FASE-2016095
关键词： self-organizing feature maps visualization processed animal proteins (PAPs) amino acid
《农业科学与工程前沿（英文）》 2021年 第8卷 第4期 页码 603-622 doi: 10.15302/J-FASE -2021397
The COVID-19 infections caused by SARS-CoV-2 have resulted in millions of people being infected and thousands of deaths globally since November 2019. To date, no unique therapeutic agent has been developed to slow the progression of this pandemic. Despite possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection has not been fully investigated. This review summarizes the mechanisms by which bacteriocins can be manipulated and implemented as effective virus entry blockers with infection suppression potential properties to highly transmissible viruses through comprehensive immune modulations that are potentially effective against COVID-19. These antimicrobial peptides have been suggested as effective antiviral therapeutics and therapeutic supplements to prevent rapid virus transmission. This review also provides a new insight into the cellular and molecular alterations which have made SARS-CoV-2 self-modified with diversified infection patterns. In addition, the possible applications of antimicrobial peptides through both natural and induced mechanisms in infection prevention perspectives on changeable virulence cases are comprehensively analyzed. Specific attention is given to the antiviral mechanisms of the molecules along with their integrative use with synthetic biology and nanosensor technology for rapid detection. Novel bacteriocin based therapeutics with cutting-edge technologies might be potential substitutes for existing time-consuming and expensive approaches to fight this newly emerged global threat.
Novel engineered proteins for mechanomaterials
Giuseppe Portale
《化学科学与工程前沿（英文）》 2020年 第14卷 第6期 页码 1122-1123 doi: 10.1007/s11705-020-1941-x
Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells
null
《医学前沿（英文）》 2018年 第12卷 第4期 页码 374-386 doi: 10.1007/s11684-018-0652-x
A family of transcription factors known as Id proteins, or inhibitor of DNA binding and differentiation, is capable of regulating cell proliferation, survival and differentiation, and is often upregulated in multiple types of tumors. Due to their ability to promote self-renewal, Id proteins have been considered as oncogenes, and potential therapeutic targets in cancer models. On the contrary, certain Id proteins are reported to act as tumor suppressors in the development of Burkitt’s lymphoma in humans, and hepatosplenic and innate-like T cell lymphomas in mice. The contexts and mechanisms by which Id proteins can serve in such contradictory roles to determine tumor outcomes are still not well understood. In this review, we explore the roles of Id proteins in lymphocyte development and tumorigenesis, particularly with respect to inhibition of their canonical DNA binding partners known as E proteins. Transcriptional regulation by E proteins, and their antagonism by Id proteins, act as gatekeepers to ensure appropriate lymphocyte development at key checkpoints. We re-examine the derailment of these regulatory mechanisms in lymphocytes that facilitate tumor development. These mechanistic insights can allow better appreciation of the context-dependent roles of Id proteins in cancers and improve considerations for therapy.
关键词： Id proteins lymphoma leukemia T cells B cells tumor suppressor oncogene
Ting Zhang, Heze Liu, Yiyuan Zhang, Wenjun Sun, Xiuwei Ao
《环境科学与工程前沿（英文）》 2020年 第14卷 第3期 doi: 10.1007/s11783-020-1214-4
关键词： Drinking water Treatment process Genotoxicity Umu test Ecological Structure-Activity Relationship
Highlights for special issue on “Large Animal Stem Cells”
Jianyong HAN
《农业科学与工程前沿（英文）》 2019年 第6卷 第1期 页码 1-2 doi: 10.15302/J-FASE-2019251
A brief review of genome editing technology for generating animal models
Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH
《农业科学与工程前沿（英文）》 2020年 第7卷 第2期 页码 123-128 doi: 10.15302/J-FASE-2019309
The recent development of genome editing technologies has given researchers unprecedented power to alter DNA sequences at chosen genomic loci, thereby generating various genetically edited animal models. This mini-review briefly summarizes the development of major genome editing tools, focusing on the application of these tools to generate animal models in multiple species.
Cryopreservation of farm animal gametes and embryos: recent updates and progress
Zhengyuan HUANG, Lei GAO, Yunpeng HOU, Shien ZHU, Xiangwei FU
《农业科学与工程前沿（英文）》 2019年 第6卷 第1期 页码 42-53 doi: 10.15302/J-FASE-2018231
Cryopreservation has undergone tremendous advances and is widely used in animal production based on decades of study of cellular permeability, freezability and empirical generalization. Several improvement are particularly important: the cryopreservation protocol has been continuously refined over the years to achieve greater reproductive performance; cryoprotective agents are more effective and less toxic than previously; there has been significant innovation in advanced cryopreservation systems and carriers. Despite this, there are still problems that urgently require practical solutions, such as remedies for cryodamage and encouraging the use of frozen–thawed porcine sperm in pig production.
关键词： vitrification gametes embryo animal production cryoprotective agent freezability
Caveolin proteins: a molecular insight into disease
null
《医学前沿（英文）》 2016年 第10卷 第4期 页码 397-404 doi: 10.1007/s11684-016-0483-6
Caveolae are a kind of specific cystic structures of lipid rafts in the cytoplasmic membrane and are rich in cholesterol and sphingolipids. In recent years, many researchers have found that both caveolins and caveolae play a role in the development of various human diseases, including coronary heart disease, hypertension, and nervous system disorders. The specific mechanisms by which caveolins induce diseases have been a topic of interest. However, a number of detailed molecular mechanisms remain poorly understood. This article focuses on the relationship between caveolin proteins and human diseases and reviews the molecular mechanisms of caveolins in disease networks.
关键词： caveolin caveolae microRNA disease signaling pathway heart tumor
Qi Lin, Xin Xu, Lihua, Wang, Qian Chen, Jing Fang, Xiaodong Shen, Liping Lou, Guangming Tian
《环境科学与工程前沿（英文）》 2017年 第11卷 第3期 doi: 10.1007/s11783-017-0924-8
关键词： Animal manure Biochar Metals Molecular species Pyrolysis
Highlights of special issue on Animal Science
Jun REN
《农业科学与工程前沿（英文）》 2017年 第4卷 第3期 页码 257-259 doi: 10.15302/J-FASE-2017165
Antimicrobial use in food animal production: situation analysis and contributing factors
Ziping WU
《农业科学与工程前沿（英文）》 2018年 第5卷 第3期 页码 301-311 doi: 10.15302/J-FASE-2018207
By measuring the quantity and ways in which antimicrobials are used, and reviewing different technical and socioeconomic factors influencing antimicrobial use at farm level, this study discusses the main knowledge gaps in antimicrobial use in food animal production and provides recommendations for future research and policy development. The review reveals that antimicrobial use in food animals exhibit strong regional and species differences, and there are still large information gaps concerning the current state of antimicrobial use. Factors associated with animal health (including antimicrobial resistance), animal health improvement, economic costs and benefits relevant to animal diseases, and potential technological alternatives or alternative systems all have an impact on antimicrobial use on the farm. There is a clear need to resolve the data gap by monitoring antimicrobial use and developing an analytical framework to better understand farmer behaviors under different technical, economic and environmental circumstances.
关键词： antimicrobial use drivers for antimicrobial use food animal production
Electrolyzed water and its application in animal houses
Weichao ZHENG,Li NI,Baoming LI
《农业科学与工程前沿（英文）》 2016年 第3卷 第3期 页码 195-205 doi: 10.15302/J-FASE-2016109
关键词： disinfection poultry and livestock slightly acidic electrolyzed water neutral electrolyzed water
Xiaoming LIU, Jia NING, Stephanie CLARK,
《化学科学与工程前沿（英文）》 2009年 第3卷 第4期 页码 436-442 doi: 10.1007/s11705-009-0251-0
关键词： -lactoglobulin processing functional alternative technology environmental
《医学前沿（英文）》 doi: 10.1007/s11684-023-1022-x
关键词： acute promyelocytic leukemia plasma proteomics plasma metabolomics cross-sectional correlation network pathogenesis treatment
标题 作者 时间 类型 操作
Visualization of amino acid composition differences between processed protein from different animal species
Xingfan ZHOU,Zengling YANG,Longjian CHEN,Lujia HAN
期刊论文
ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC
期刊论文
Comparative genotoxicity of water processed by three drinking water treatment plants with different water
Ting Zhang, Heze Liu, Yiyuan Zhang, Wenjun Sun, Xiuwei Ao
期刊论文
A brief review of genome editing technology for generating animal models
Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH
期刊论文
Cryopreservation of farm animal gametes and embryos: recent updates and progress
Zhengyuan HUANG, Lei GAO, Yunpeng HOU, Shien ZHU, Xiangwei FU
期刊论文
The speciation, leachability and bioaccessibility of Cu and Zn in animal manure-derived biochar: effect
Qi Lin, Xin Xu, Lihua, Wang, Qian Chen, Jing Fang, Xiaodong Shen, Liping Lou, Guangming Tian
期刊论文
Antimicrobial use in food animal production: situation analysis and contributing factors
Ziping WU
期刊论文
Changes in structure and functional properties of whey proteins induced by high hydrostatic pressure:
Xiaoming LIU, Jia NING, Stephanie CLARK,
期刊论文
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